In Western New York State's Monroe County, like in other New York counties, the rate of childhood lead poisoning was alarming, especially among low-income children. In response, the Coalition to Prevent Childhood Lead Poisoning was established in 2000 with a mission to "end childhood lead poisoning in Monroe County in 2010". Recognized by then-U.S. Senator Hilary Rodham Clinton as a "national model" for reducing childhood lead poisoning, the county coalition's efforts have cut childhood lead poisoning rates by 72% in eight years.

African Americans in Louisville, Kentucky, as in the rest of the U.S., experience greater health inequities compared to other racial and ethnic groups. This population, in particular, disproportionately experiences illness, violence-related injuries and premature death. In response, the Louisville Metro Department of Public Health and Wellness's Center for Health Equity is tracing the pathway from illness and injury to the community conditions, norms and root factors that lead to poor health and inequity in the first place. By building capacity among historically disenfranchised neighborhoods, CHE is leading an urban movement to promote equal opportunities for health and safety.

Developed by the Seattle Housing Authority, Cultivating Communities is a neighborhood gardening program for low-income communities in Seattle, Washington. The program has provided lead-free gardening plots, increased availability of healthy food, and promoted social connections and trust between community members.

An innovative partnership focusing on Roxbury and Dorchester in Boston, Massachusetts uses affordable techniques to minimize exposure to lead in inner-city yards-a contemporary environmental hazard linked to developmental disabilities and learning delays, particularly among children under six, living in older, urban homes.