As states and jurisdictions continue to plan for the use of opioid settlement funds, it is critical that they consider the importance of primary prevention strategies, impact measurement, and sustainability. In the first part of this webinar, briefly hear from Prevention Institute about how decision-makers can leverage primary prevention in opioid remediation activities and how they complement and strengthen harm reduction, treatment, and long-term recovery strategies. Also learn from a team at RTI International about the considerations for monitoring, evaluating, and tracking progress and outcomes of strategies and activities facilitated through the use of opioid settlement funding over multiple years. Explore principles for effective monitoring and evaluation (M&E) and hear how decision-makers at the state and community level can adapt and apply an M&E Framework to ensure transparency, accountability, and sustainability. You’ll leave this webinar with new frameworks for prevention and measuring impact to consider. Additionally, you’ll be guided toward a brand-new online resource hub that can support your ongoing learning, planning, implementation, and evaluation efforts related to using settlement funds. Prevention Institute and its partners–Big Cities Health Coalition, ChangeLab Solutions, SheRay's & Associates LLC, and RTI International– are working collectively to increase an understanding of the evidence-base for preventing substance use, misuse, and overdose; build the capacity of decision-makers to make choices informed by science, contextual, and lived/living experience; and strengthen partnerships to enhance the effectiveness of using settlement funding. This project is supported by Cooperative Agreement Number NU38OT000305 awarded to Prevention Institute and funded by the Centers for Disease Control and Prevention (CDC). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of CDC/HSS.